Editing of Nuclear Antigen-Reactive B Cells Tolerance to DNA by Impairing Receptor Lupus Susceptibility Genes May Breach
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Apoptotic marginal zone deletion of anti-Sm/ribonucleoprotein B cells.
CD40L is excessively produced in both human and murine lupus and plays a role in lupus pathogenesis. To address how excess CD40L induces autoantibody production, we crossed CD40L-transgenic mice with the anti-DNA H-chain transgenic mouse lines 3H9 and 56R, well-characterized models for studying B-cell tolerance to nuclear antigens. Excess CD40L did not induce autoantibody production in 3H9 mice...
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Self-reactive B cells are tolerized at various stages of B-cell development and differentiation, including the immature B-cell stage (central tolerance) and the germinal center (GC) B-cell stage, and B-cell tolerance involves various mechanisms such as deletion, anergy, and receptor editing. Self-reactive B cells generated by random immunoglobulin variable gene rearrangements are tolerized by c...
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Antibody diversity is generated through the random recombination of immunoglobulin gene segments. As a consequence of this stochastic process, antibodies recognizing self-antigens can also be produced. Continued antibody gene rearrangement, termed receptor editing, is an important mechanism of central B cell tolerance that serves to alter the antibody specificity of developing B cells. Although...
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تاریخ انتشار 2007